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This detoxifying action is crucial for liver health, which impacts the entire bodys ability to maintain homeostasis

Adv Nutr 6(1):6472 Steane SE, Cuffe JS, Moritz KM (2023) The role of maternal choline, folate and one-carbon metabolism in mediating the impact of prenatal alcohol exposure on placental and fetal development

doi: 10.26402/jpp.2022.6.07 136 WuSWuXWangQChenZLiLChenHet al

In a Phase 2 obesity trial of retatrutide published in the New England Journal of Medicine in 2023, nausea, diarrhea, vomiting and constipation were cited as the most common adverse events, with higher doses associated with more severe problems

The study, published in Nature Health , covers more than half a decade of posts from nearly 70,000 Reddit users and highlights two main classes of symptoms that warrant further study: reproductive symptoms, including irregular menstrual cycles, and temperature-related complaints, such as chills and hot flashes