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Therefore, damage to the glutathione system may lead to proinflammatory-induced oxidative stress in chondrocytes, especially in the process of senescence (McCutchen et al., 2017
Increasing evidence suggests that microbial communities residing within tumors or at distant mucosal sites can drive resistance to anticancer therapies through diverse mechanisms, including modulation of drug metabolism and transport, induction of ROS, impairment of DDR, activation of oncogenic signaling, and suppression of antitumor immunity