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seek immediate medical attention for severe reactions Diabetic retinopathy : Monitor vision changes, especially in patients with diabetes Increased heart rate : May cause elevated heart rate, particularly in patients with cardiac conditions Suicidal behavior and ideation : Monitor for mood changes or depressive symptoms Contraindications Semaglutide should not be used in the following cases: Pregnancy: Not recommended (classified as Pregnancy Category C) Breastfeeding: Effects unknown

After 48 h, cells were fixed with 4% PFA for 45 min and then stained with DAPI for 15 min

& Mann, M

But there is significant individual variation