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Almeida-Santos AC, Novais C, Peixe L, Freitas AR
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(2) transhydrogenases, to reduce oxidized centers on DNA, proteins, and other biomolecules
Moreover, UA-induced inflammation and oxidative stress can also trigger endoplasmic reticulum (ER) stress, decreased nitric oxide bioavailability and produce peroxynitrite (ONOO-), a very powerful radical, which contributing to cellular dysfunction and apoptosis
Both peptides activate similar pathways, but subtle differences in receptor affinity may influence results for specific applications
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