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It has been reported that renal blood flow resistance can increase to 23 times the normal level after RIRI, resulting in a significant decrease in renal perfusion volume [43]
These therapies should be presented as investigational or clinician-directed rather than as proven methods for reversing chronic kidney disease
The 2008 Lancet trial that established tesofensine's efficacy also documented cardiovascular adverse events in 18% of participants at the 1mg dose
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