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10.2147/OTT.S235730 38 FengQ.YaoQ.LiB.XieY.ZhangH.XuZ.et al (2020)

Although these differences were not clinically significant, the decision of administering dapalgiflozin to cirrhotic patients should be individually assessed because the long-term safety profile and efficacy have not been specifically studied in this population.81 Caution should be even greater when hepatic dysfunction is combined with renal impairment