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The research appears to be at a standstill following the cancelled 2015 Phase I study
It lists individual metabolic rate as a factor, noting a faster metabolism may shorten symptom duration while slower clearance can extend nausea and appetite loss beyond ten days
What should I do if laxatives and hydration aren't working
If discomfort continues beyond a month, a medical review helps rule out hydration, nutrition, or dosing issues
A plateau on a stable dose is an expected endpoint rather than proof that semaglutide has stopped working
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