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Indirect calorimetry showed that KO mice displayed a higher respiratory exchange ratio (RER), indicative of a shift toward carbohydrate utilization

conceived the study

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Swamynathan, M.M., Kuang, S., Watrud, K.E., Doherty, M.R., Gineste, C., Mathew, G., Gong, G.Q., Cox, H., Cheng, E., Reiss, D., Kendall, J., Ghosh, D., Reczek, C.R., Zhao, X., Herzka, T., Spokaite, S., Dessus, A.N., Kim, S.T., Klingbeil, O., Liu, J., Nowak, D.G., Alsudani, H., Wee, T.L., Park, Y., Minicozzi, F., Rivera, K., Almeida, A.S., Chang, K., Chakrabarty, R.P., Wilkinson, J.E., Gimotty, P.A., Diermeier, S.D., Egeblad, M., Vakoc, C.R., Locasale, J.W., Chandel, N.S., Janowitz, T., Hicks, J.B., Wigler, M., Pappin, D.J., Williams, R.L., Cifani, P., Tuveson, D.A., Laporte, J., Trotman, L.C., 2024