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They travel through your blood

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Abstract Heart failure and cognitive impairment emerge as public health problems that need to be addressed due to the aging global population

Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A

This is not a semantic distinction, since confirming the primary site will dictate the patients clinical stage and the type of therapy they will undergo