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[170] [171] In June 2025, the European Medicines Agency recommended that the product information for semaglutide medicines be updated to include non-arteritic anterior ischemic optic neuropathy (NAION) as a very rare side effect, [172] while the World Health Organization concluded that the risk management plan for semaglutide should be revised to include NAION as a potential risk

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As a general guideline, Semaglutide GLP-1 injections are typically prescribed to individuals with a BMI of 30 or above or 27 and above with at least one weight-related condition, such as high cholesterol, osteoarthritis, or sleep apnea

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