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"Once you have achieved your desired results, stop using hydroquinone daily and only use it if the hyperpigmentation reappears," says Aegean Chan, M.D., a board-certified dermatologist based in Santa Barbara, California

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Long-term consequences of arterial stiffening include negative impacts on brain function, BBB breakdown (Krizbai et al., 2005), reduced CBF, and blunted cerebrovascular reactivity (Loureno et al., 2017)