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Evidence from preclinical and clinical studies suggests heterogeneous effects of GLP1RAs on cancer risk: the incidence of hepatocellular, oesophageal, endometrial, ovarian and prostate cancers might be reduced, whereas safety concerns persist with respect to thyroid (both medullary and non-medullary) carcinomas
GLP-1 and GLP-1RAs have also shown to exert anti-depressive effects by reversing many maladaptive brain changes relevant to depression (13)
For patients whose constipation is limiting adherence or quality of life, individualized medical management often makes the difference between stopping therapy and long-term success
Wu, S.-X
Brian Bekker Hansen is an employee of Novo Nordisk A/S
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