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CJC-1295 without DAC (Mod GRF 1-29): 100 to 300 mcg administered subcutaneously 1 to 3 times daily, often before bed and/or upon waking
Significant hurdles remain, particularly the current absence of reliable biomarkers for identifying OXPHOS-dependent patient subgroups
At 1 mg its occupancy sits near 1%, and liver fat still fell 51% over 48 weeks in the trial participants who started with fatty liver. Natural glucagon reaches a similar 0.5 to 5% engagement during a fast, so 1% is not an unusually small signal
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