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Semaglutide is contraindicated in patients with a personal or family history of certain types of thyroid cancer, specifically thyroid C-cell tumors such as medullary thyroid carcinoma (MTC), or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)

(1) Also known as GLP-1 RA (receptor agonists), semaglutide and tirzepatide work by hindering the release of glucagon , the hormone that increases blood sugar

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading

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In an 8-week study using low-dose liraglutide (0.6 mg/day) in patients with type 2 diabetes no weight or fat loss was produced, but both fasting and postprandial glucose were substantially reduced, but neither fasting nor postprandial insulin (or C-peptide) response was increased [19]