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New England Journal of Medicine, 384, 989-1002 Jastreboff AM, et al

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Patients taking oral contraceptives should be aware that tirzepatide may decrease the absorption of these medications due to delayed gastric emptying, potentially requiring backup contraception for 4 weeks after initiation and after each dose increase

Tirzepatide, a new era of dual-targeted treatment for diabetes and obesity: A mini-review