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The concept behind CagriSema reflects a growing understanding that obesity involves multiple overlapping hormonal systems

Worryingly however, 26.8% of patients had to discontinue the trial due to the severity of side-effects, although it must be noted that this was in part due to the lack of a run-in (A time frame where drug dosage is started from a low dosage and then escalated over time until the highest tolerable dose for the patient is reached) [40]

Future clinical studies need to be larger in scale in order to refute or confirm what earlier studies have found