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Long-term safety, potential adverse effects, and inconsistent clinical outcomes remain challenges that must be addressed
Where estrogen works to restore the hormonal environment that governs fat distribution and metabolic regulation, GLP-1 therapy directly reduces caloric intake by recalibrating appetite signaling, improves glycemic control through multiple mechanisms, and drives the reduction of visceral fat mass that estrogen alone cannot reliably produce in the setting of significant metabolic burden
doi: 10.1002/9780470999615.ch44
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