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This mechanism contributes to DSIPs broader effects on neuronal function and communication

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Stimulation with 6-hydroxydopamine (6-OHDA) markedly downregulates nuclear factor erythroid 2related factor 2 (NRF2) expression in PC-12 cells, elevates Fe 2+ and reactive oxygen species (ROS) levels, suppresses glutathione peroxidase 4 (GPX4), promotes both ferroptosis and apoptosis, inhibits cell proliferation, and causes neuronal damage

That is a 99.7% animal-to-human ratio

doi: 10.1183/09031936.97.10071535 16 De FloraS.BalanskyR.La MaestraS