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Research highlights NAD+ Increased cellular NAD+ via nicotinamide pool NNMT Enzyme overexpressed in obese adipose tissue Anti-adip Reduced lipid accumulation and adipocyte differentiation SIRT1 Downstream sirtuin activation via NAD+ elevation Research notes Adipocyte research: In vitro models show reduced lipid accumulation and pre-adipocyte differentiation upon NNMT inhibition

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FEBS J 282:11901213 Perna V, Meyer AS, Holck J, Eltis LD, Eijsink VGH, Agger JW (2020) Laccase-catalyzed oxidation of lignin induces production of H 2 O 2

Cigarette smoke-induced trophoblast cell ferroptosis in rat placenta and the effects of L-arginine intervention