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Tirzepatide acts simultaneously on two incretin receptors: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
The intranasal route is preferred because it delivers the peptide directly to the central nervous system through the olfactory mucosa
The peptide also showed promise for reducing the size of endometrial implants, though larger controlled trials are needed to confirm these findings
People who are pregnant, breastfeeding, sensitive to stimulants, or on blood-pressure or arrhythmia meds should consult a clinician
The Medicines and Healthcare products Regulatory Agency (MHRA) has earlier revised the product information of semaglutide, indicating a rare risk of vision loss
