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38 A key benefit of GLP-1R agonists is the glucose-dependent insulinotropic function, with reduction in blood glucose only in hyperglycemia, eliminating the hypoglycemia risk of many other antidiabetic drugs
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Combining MDSC checkpoint blockade with ICIs could therefore break the immune resistance conferred by MDSCs and facilitate deeper penetration of T cells, CAR-T cells, CAR-NK cells, or CAR- Macrophages into the tumor site
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