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Physiologically, oral melanocytes may or may not produce melanin, however non-physiological alterations related to genetic, metabolic, endocrine, chemical and physical factors, and to infections, inflammatory and neoplasic processes could interfere in the oral pigmentation [12] (Figure 1)
doi:10.1038/273120a0
Subbian S, Tsenova L, OBrien P, Yang G, Koo MS, Peixoto B, Fallows D, Dartois V, Muller G, Kaplan G
The main goal is to limit disease activity and induce repigmentation
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