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15.5 Alternative Therapies During Pregnancy Safer alternatives may include insulin or other agents with established maternal-fetal safety profiles

The contrast is stark

When semaglutide is not stored within the recommended temperature ranges, it may lose its effectiveness

When tirzepatides extra makes clinical sense: Severe obesity with stacked risks (BMI over 30, diabetes, hypertension, MASLD, sleep apnea, etc.) High orthopedic burden (advanced knee or hip arthritis, foot/ankle issues) Presurgical timelines (preparing for bariatric, orthopedic, or heart surgeries) When semaglutide may be the better fit: Mild to moderate obesity with lower shortterm risk

Track daily for at least the first eight weeks