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In cardiac remodeling, cardiomyocytes in a failing heart undergo maladaptive changes including abnormalities in gene expression, mechanical properties, metabolic pathways, and the extracellular matrix (ECM) 28
These symptoms improve with continuous use, as only 3% and 9% of patients reported nausea with the long- or short-acting GLP-1RA after 6 months of use, respectively (72)
Despite LCs known role in lipid metabolism, the variability in findings across studies suggests that its effects may differ depending on patient populations, study design, dosage, and other factors
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Among them, the anti-inflammatory effect has attracted the most attention, because in many diseased states, besides specific symptoms the body is generally in a state of chronic inflammation
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