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These medications work by mimicking the natural GLP-1 hormone, which helps regulate appetite and food intake

In light of glucagons ability to increase glucose production, and the documented beneficial effects of glucagon signal inhibition for the treatment of type 2 diabetes, at first glance it seems counter-intuitive that glucagon could be used in unimolecular combinations with GLP-1 to treat obesity and type 2 diabetes [114]

A 2026 follow-up study showed a similar boost for tirzepatide, where women pairing the drug with HRT achieved a 19% weight reduction compared to 14% for those taking the medication alone

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In healthy individuals, studies indicate that the effects of these two hormones are additive (48, 54)