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For the treatment-regimen estimand, 4 each dose of orforglipron led to statistically significant A1C reductions
It is common to feel a mild recurrence of nausea for a day or two after a dose increase
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However, it has previously been reported that acute exposure to GLP-1 does not affect energy metabolism in -cells 15
It addresses the pitfalls above through two core strategies: 1) a highly personalized low and slow titration protocol aimed at maximizing tolerability and finding the right dose for each individual, in combination with 2) deep lifestyle integration using behavioral science focused on ensuring patients build healthy habits alongside the medication
