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All efforts were made to minimize animal suffering and reduce the number of animals used while maintaining statistical validity
Chen X, Lan X, Roche I, Liu R, Geiger JD
Published human evidence includes topical applications over defined periods, diabetic-ulcer wound protocols, and a registered topical acute-wound trial, while there is no FDA-approved injectable GHK-Cu label that establishes a standard dose [2], [3], [7], [8]
For example, topical administration makes sense for localized skin wounds, while systemic delivery via ingestion or inhalation may be preferable for internal ulcers [45]
In hepatocellular carcinoma (HCC) studies, ADI-PEG-20 has been shown in early clinical trials to make HCC animal models and patients more sensitive to FOLFOX chemotherapy through arginine depletion
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