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Lower bioavailability than injection
And even topically, the class is not uniformly effective a controlled irradiated-rat study found no benefit of topical GHK-Cu on wound or vessel outcomes [11]
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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Under experimentally induced oxidative stress conditions using hydrogen peroxide, BPC 157 appeared to support fibroblast survival relative to untreated controls
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