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Diabetes, Obesity & Metabolism, 23 (2), 581588
In the first trial, liraglutide lowered weight by 12 pounds and improved glucose tolerance relative to placebo over 4 months in 103 patients with schizophrenia spectrum disorders (Larsen JR et al, JAMA Psych 2017;74(1):719728)
Novo Nordisk plans on seeking regulatory approval for semaglutide as a treatment for cardiovascular disease in the United States and Europe in the near future
GLP-1 receptor agonists are prescribed to manage type 2 diabetes by regulating blood sugar and, in some cases, to support weight loss
It produces endogenous peptides for mucosal protection, employs peptide transporters for nutrient absorption, and maintains a peptide-rich environment for immune regulation
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