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Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways

Endogenous glutathione adducts

& Sohal, J

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This polarization is also mediated via the Hedgehog/GLI1 pathway, where LINC00958 facilitates GLI1 activation, driving IL-4 transcription in macrophages and enhancing the M2 phenotype