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While activating ARC AgRP/NPY neurons has been shown to be both aversive [136] and rewarding [144] depending on the duration of activation, the positive valence associated with inhibiting ARC AgRP/NPY neurons [136] lends itself well to targeting these neurons for obesity drug development

This represents a unique pharmacological profile for studying receptor cross-talk

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Toxicity by NSAIDs counteracted by stable gastric pentadecapeptide BPC 157