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Collectively, these multivariable findings support a 2-step clinical strategy: selecting the agent with the best GI tolerability profile for the individual patient, then anticipating long term persistence issues, chiefly in IBS-M and publicly insured populations (Fig
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Any mole that changes shape, color, or size, or begins to bleed, warrants stopping and seeing a dermatologist
Despite their clinical uses, these drugs are strongly reinforcing, and their long-term use at high doses is linked with potential addiction, especially when they are rapidly administered or when high-potency forms are given
This initial period allows the body to adjust to the medication and reduces the likelihood of gastrointestinal side effects
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