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Przewlocki R et al

While proliferation slows in ACLY KO HCC cells in the absence of acetate, the cells retain viability and continue to proliferate in the absence of exogenous acetate, in contrast to ACLY KO MEFs (Figure 1E

Its biosynthesis is catalyzed by sphingomyelinase, a phosphodiesterase that hydrolyzes the membrane sphingolipid sphingomyelin (SM) to generate ceramide (Zeidan and Hannun, 2010)