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Consultado el 21 de abril de 2026
4.3 Bone-targeted delivery systems Efficient delivery of therapeutic agents to bone tumors is complicated by the unique physiological features of bone tissue, including its dense mineralized matrix, low blood flow in certain regions, and the presence of the bone marrow niche (59)
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Virus-induced hypoxia/Warburg effect SARS-CoV-2 hijacks host cellular metabolic machinery to extract adequate energy and carbon skeletons to facilitate viral entry and facilitate molecular constructions for viral progeny inside a host cell for replication and propagation
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