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299 Lactate secreted by differentiated cancer cells (CDCs) is metabolized by CSCs into acetyl-CoA, promoting histone H3K27 acetylation, MYC activation, and CSC maintenance
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doi: 10.1097/QAD.0000000000001875 36
The 25-mg/kg dose reduced these parameters by 48.8%, 30.3%, 33.4%, and 47.5%, respectively, while the 50-mg/kg dose showed more pronounced effects, reducing them by 67.9%, 58.6%, 60.4%, and 73.6%, respectively, in comparison with the TAA group (Figures 4AD)
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