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The 18% discontinuation rate at the highest dose means roughly 1 in 5 people cannot tolerate retatrutide at maximum dose

It boosts collagen production, making skin firmer and more elastic over time

Causes and considerations: Direct taste sensation from the copper-containing complex Post-nasal drip from nasal formulations Transient effect often mitigated with delivery technique adjustments The metallic taste is not typically a clinically meaningful adverse effect, but it can be bothersome enough that patients discontinue therapy

J Obes Metab Syndr 2023;32:2545.ArticlePubMedPMC 87

The systems effective current capability increases, but chemistry limits remain the same