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doi: 10.3389/fmars.2020.00467 24 AlbanoGDMontalbanoAMGagliardoRProfitaM

Adverse event terminology standardization was achieved through implementation of the Medical Dictionary for Regulatory Activities (MedDRA), which employs a five-tier hierarchical classification system: System Organ Class (SOC), High-Level Group Term (HLGT), High-Level Term (HLT), Preferred Term (PT), and Lower-Level Term (LLT)

Its roles span immune cell activation, collagen biosynthesis, neurotransmitter synthesis, and antioxidant regeneration

But the same disruption means the skin is more reactive to potential irritants in the formulation, including preservatives, fragrances, surfactants, and even some peptide stabilizers

Archives of Facial Plastic Surgery, 3(1), 28-32