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Examples Acarbose (Precose) Dosage Initial: 25 mg three times daily with first bite of each meal Maximum: Generally 300 mg, with meals, per day Miglitol (Glyset) Dosage Initial: 25 mg three times daily at the start of each meal Maximum: 50 mg three times daily Possible side effects include: Gastrointestinal: flatulence (gas), abdominal discomfort, diarrhea High-carbohydrate diet may worsen these side effects Gastrointestinal side effects usually become less pronounced with continued use Liver enzyme (transaminases) elevation Sulfonylureas Primary mechanism(s) of action Sulfonylureas stimulate insulin release by pancreatic beta cells

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MetS patients NO levels also increased with metformin (97)

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