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Both carry a boxed warning about thyroid C-cell tumors observed in rodents, although this has not been demonstrated in humans

Some patients are switched to 5 mg/mL during maintenance to cut the injection volume in half

Furthermore, it slightly reduced the increase of glucose transporter types 1 and 4 (GLUT1/4) during adipogenesis and led to a rise of GLP-1 mRNA, though protein levels remained unchanged

Importantly, whether considering the targeting of the T or B cell in type 1 diabetes, sufficient long-term benefits via systemic cell pool depletion comes with an inherent risk of introducing equally long-term or even irreversible changes to the immune system