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These are mechanisms observed primarily in animal and cell-culture models, and they remain an active area of investigation rather than settled clinical fact

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^ Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial

In this article, we review the history of DSIP, discuss what researchers currently understand about how it may work, and highlight the limitations of existing research