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4 Gut microbiota dysbiosis and abnormal activation of the innate immune system 4.1 Evidence for the association between complement components and schizophrenia Current studies have identified elevated transcript levels of complement components (C1qA, C3, C4, C5) in patients with schizophrenia (114) (see Table 2 ), suggesting, albeit not entirely consistently, that increased activation of the classical complement pathway may be associated with SZ