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The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models
Russo, A
Because AOD-9604 does not suppress appetite mechanisms in the first place, there is no adaptation of hunger-regulating neurons and no compensatory hunger amplification when the peptide is stopped
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1998;13(6):14191422 Lenzi A, Gandini L, Picardo M
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