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They enhance autophagy and reduce lipotoxicity-induced hepatocyte apoptosis, thereby preserving the integrity of liver parenchyma ( action to enhance anti-fibrotic efficacy ( In summary, GLP-1 receptor agonists exert anti-fibrotic effects in MASLD through the inhibition of hepatic stellate cell activation, the modulation of profibrotic signaling pathways, and the promotion of hepatocyte regeneration
This should not be viewed as a failure of the medication to work, but as a consequence of weight loss associated metabolic adaptation and hormonal response that results in slower metabolism and increased hunger
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doi: 10.22038/ijbms.2020.39815.9436 170 RodaGChien NgSKotzePGArgolloMPanaccioneRSpinelliAet al
Metformin is also a diabetes medication that may cause weight loss, but it belongs to a different drug class than Ozempic
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