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In this review, we generally summarized the feasible strategies for attenuating mitochondrial dysfunction and restoring their function, including promoting mitochondrial biogenetics and energetics, reducing mitochondrial ROS, enhancing mitophagy and regulating mitochondrial dynamics
Approved agents like suvorexant (Belsomra) and low-dose doxepin have Phase III RCT data in hundreds to thousands of patients
Figueiredo RR, de Azevedo AA, Penido Nde O
These rules include pharmacopoeia standards, stability studies, and impurity analysis
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