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In summary, there is evidence for PKC overactivity in bipolar disorder, which is attenuated with anti-manic agents, including lithium, as symptoms improve
Prolonged exposure to Li during BDs therapy can result in chronic tubulointerstitial nephritis, leading to chronic kidney disease (lithium nephropathy), hyperparathyroidism, and hypercalcemia 7
Sustained-release formulations like Glutathione-SR bypass digestive breakdown, ensuring better absorption and consistent cellular protection