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MPTP is an agent used to mimic the damage caused by Parkinsons disease [11] Furthermore, BPC-157 was found to be effective in improving memory, locomotion and coordination and relieving neuronal damage in rats with stroke induced by bilateral clamping
There is, however, evidence to support considering closer follow-up when initiating a GLP-1 RA, particularly if rapid improvement in glycemic control is anticipated, following a baseline dilated fundus examination performed around the time of therapy initiation
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Weight Loss and Cardiovascular Outcomes Although semaglutide led to an average placebo-adjusted weight loss of 8.5% (Semaglutide arm lost 8.5% more body weight than those who took the placebo), its cardiovascular risk reduction was not linked to how much weight patients lost
From a pharmacological standpoint, several considerations are relevant: Gastrointestinal effects : Retatrutide, like other GLP-1-based therapies, commonly causes nausea, vomiting, diarrhoea, and reduced appetite
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
