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GLP-1 receptor agonists undergo renal clearance, meaning reduced kidney function may alter how long these medications remain active in the body and affect dosing strategies
Abbreviations DM: Diabetes mellitus TD1: Type 1 diabetes TD2: Type 2 diabetes DYRK1A: Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 1A SIK: Salt-Inducible Kinase TGF-: Transforming Growth Factor- EGF: Endothelial Growth Factor GLP1: Glucagon-Like Peptide-1 CDK: Cyclin-Dependent Kinase GABA: -Amino Butyric Acid GLP1R: Glucagon-Like Peptide 1 Receptor GPCR: G ProteinCoupled Receptor hESC: Human Embryonic Stem Cells hiPSC: Human Induced Pluripotent Stem Cell IL: Interleukin NFAT: Nuclear Factor of Activated T Cells TGF: Transforming Growth Factor TNF: Tumor Necrosis Factor DPP-4: Dipeptidyl Peptidase-4 PPIs: Proton Pump Inhibitors References Abdolazimi Y, Zhao Z, Lee S, Xu H, Allegretti P, Horton TM, et al (2018) CC-401 promotes -cell replication via pleiotropic consequences of DYRK1A/B inhibition
Phase 2 subjects on 150mg/day averaged 13.8% weight loss with no muscle loss reported
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8.2 Lactation Risk Summary There is no information regarding the presence of pioglitazone or alogliptin in human milk, the effects on the breastfed infant, or the effects on milk production
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