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However, even more potent GLP-1 RAs have limitations, including gastrointestinal adverse events and loss of lean mass [7]

Synthetic hormones from contraceptives or hormone replacement therapy alter the hormonal backdrop that influences gastric motility and glucose metabolism, so tolerability may differ from an unmedicated cycle

Non-adherence to diabetes guidelines in primary care - the enemy of evidence-based practice

But that should not downplay the very real experiences of people who have struggled with obesity and related health conditions for decades