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At later time points, such as 10 s after the onset of forepaw stimulation, CBV responses increased further and were predominantly localized in layer 4, rather than the superficial layers (late CBV response in layers 2/3 and 4: 1.98 0.51% and 3.43 0.73%, respectively, averaged over 1120 s, n = 8 mice for hM4Di group, one-way ANOVA repeated test, multiple comparison with turkey, p = 0.0009) (pre-CNO, Fig

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Administration differs between the two peptides