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(Regulatory Toxicology and Pharmacology, 2020) reported a preclinical safety package designed to support potential drug development

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Pharmacokinetics, stability, and degradation Naked nucleic acids have poor in vivo stability and can degrade in the bloodstream

Pregnant or breastfeeding women are typically advised against use due to the unknown risks

However, these methods fail to adequately address the shared oxidative mechanisms underlying toxicity, specifically the accumulation of ROS and resulting oxidative stress, which are common consequences of chemotherapeutic agents used in ALL treatment, including anthracyclines, vincristine and 6-MP